A/Prof Brett Collins

Assoc. Prof. Brett Collins is a Group leader at the University of Queensland Institute for Molecular Bioscience, and an NHMRC Senior Research Fellow. His lab is interested in understanding how molecular interactions between proteins and lipids control intracellular membrane trafficking. Trafficking is essential for normal cellular function and is involved in many different diseases, but is emerging as particularly important in neurodegenerative diseases such as Alzheimer’s and Parkinson’s. The lab is focussed on dissecting the molecular choreography of membrane transport through structural biology and biophysical approaches including X-ray crystallography and cryoelectron microscopy. Current interests include (i) endosomal trafficking by the retromer complex and the sorting nexin protein family, (ii) the formation of plasma membrane structures called caveolae, and (ii) the mechanisms of synaptic vesicle fusion controlled by SNARE proteins.