Dr Alexander Combes
Based at the Murdoch Children’s Research Institute and the University of Melbourne, Dr Combes endeavours to understand the genetic and cellular control of kidney development as a model of organ formation and congenital disease. A key interest is the nephron progenitor population. Nephron progenitors are a transient stem/progenitor cell population that give rise to the filtration units of the adult kidney.
His team are interested in understanding the regulation of nephron progenitor self-renewal and commitment, and how this influences kidney size and functional capacity. They take a multidisciplinary approach integrating molecular genetics, quantitative 3D imaging, single cell genomics, and mathematical modelling.